Factor XIII Deficiency Associated With Noonan Syndrome

Zeni Kharel; Anjan Katel; Arun Neupane; Pradumna Panday; Madan Aryal

doi:10.7759/cureus.14150

Factor XIII Deficiency Associated With Noonan Syndrome

Cureus. 2021 Mar 27;13(3):e14150. doi: 10.7759/cureus.14150.

Authors

Zeni Kharel¹, Anjan Katel², Arun Neupane³, Pradumna Panday², Madan Aryal⁴

Affiliations

¹ Internal Medicine, Rochester General Hospital, Rochester, USA.
² Medicine, Kathmandu University School of Medical Sciences, Dhulikhel, NPL.
³ Nursing and Critical Care, Alta Bates Summit Medical Center, California, USA.
⁴ Medicine, Enloe Medical Center, Enloe Regional Cancer Center, California, USA.

Abstract

Noonan syndrome (NS) is an autosomal dominant disorder with multisystem involvement. NS can be associated with bleeding disorders due to defects in platelet function or coagulation factors and diagnosis can be challenging. Factor XIII (FXIII) deficiency is uncommon in patients with NS. We present a case of NS who presented with bleeding in both thighs and was diagnosed to have deficiency in FXIII.

Keywords: bleeding; factor xiii deficiency; noonan syndrome.

Publication types

Case Reports