Preparation of a novel amino functionalized ion-imprinted hybrid monolithic column for the selective extraction of trace copper followed by ICP-MS detection

Jia-Jun Fei; Xiao-Hong Wu; Yue-Lun Sun; Ling-Yu Zhao; Hong Min; Xiao-Bing Cui; Yi-Jun Chen; Shu Liu; Hong-Zhen Lian; Chen Li

doi:10.1016/j.aca.2021.338477

Preparation of a novel amino functionalized ion-imprinted hybrid monolithic column for the selective extraction of trace copper followed by ICP-MS detection

Anal Chim Acta. 2021 Jun 1:1162:338477. doi: 10.1016/j.aca.2021.338477. Epub 2021 Apr 8.

Authors

Jia-Jun Fei¹, Xiao-Hong Wu², Yue-Lun Sun¹, Ling-Yu Zhao¹, Hong Min², Xiao-Bing Cui³, Yi-Jun Chen¹, Shu Liu², Hong-Zhen Lian⁴, Chen Li⁵

Affiliations

¹ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China.
² Technical Center for Industrial Product and Raw Material Inspection and Testing, Shanghai Customs, Shanghai, 200135, China.
³ College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
⁴ State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry & Chemical Engineering and Center of Materials Analysis, Nanjing University, Nanjing, 210023, China. Electronic address: hzlian@nju.edu.cn.
⁵ Technical Center for Industrial Product and Raw Material Inspection and Testing, Shanghai Customs, Shanghai, 200135, China. Electronic address: li_chen@customs.gov.cn.

PMID: 33926696
DOI: 10.1016/j.aca.2021.338477

Abstract

In this work, a novel amino functionalized Cu(II) ion-imprinted organic-inorganic hybrid monolithic column (Cu(II)-IIHMC) was prepared via one-pot co-condensation and the combination of sol-gel and ion-imprinting techniques in a fused capillary. The Cu(II)-IIHMC was used as solid phase microextraction (SPME) matrix followed by inductively coupled plasma-mass spectrometry (ICP-MS) for the analysis of trace Cu(II). The prepared Cu(II)-IIHMC has good mechanical strength, stable imprinting sites and homogeneous structure of network skeleton with large flow-through pores by optimizing the synthesis process. Under the optimized conditions, the Cu(II)-IIHMC can selectively adsorb Cu(II) with the adsorption capacity of 3.13 mg g^-1. With enrichment factor of 10-fold, the calibration curve was established in the range of 0.05-50 μg L^-1 with r² of 0.9992 and the detection limit was 0.008 μg L^-1 for Cu(II). Compared with the non-imprinted hybrid monolithic column (Cu(II)-NIHMC), the Cu(II)-IIHMC possesses better selectivity, anti-interference ability and adsorption capacity. The Cu(II)-IIHMC can specifically capture the target ion in the presence of competitive ions, with the selectivity coefficients exceeding 39.4. The protocol was validated by analyzing Certified Reference Materials of standard sediment, soil and iron ore, and the results were in good agreement with certified values. Moreover, the proposed in-tube SPME procedure can not only preconcentrate trace Cu(II), but also effectively reduce the matrix effect and powerfully eliminate the interference from the main metals in real samples. Therefore, the developed SPME-ICP-MS method with facile preparation, specific selectivity, high sensitivity and efficient analysis, was applied in the determination of trace Cu(II) in environmental and mineral samples with the recoveries of 89.8-111.8% in all spiked samples.

Keywords: ICP-MS; Ion-imprinted hybrid monolithic column; Solid phase microextraction; Specific selectivity; Trace Cu(II).