The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS

Jasmine Harley; Benjamin E Clarke; Rickie Patani

doi:10.3390/antiox10040552

The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS

Antioxidants (Basel). 2021 Apr 2;10(4):552. doi: 10.3390/antiox10040552.

Authors

Jasmine Harley^{1

2}, Benjamin E Clarke^{1

2}, Rickie Patani^{1

2

3}

Affiliations

¹ Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
² The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
³ National Hospital for Neurology and Neurosurgery, University College London NHS, London WC1N 3BG, UK.

Abstract

RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways.

Keywords: ALS; RNA binding protein; mitochondrial dysfunction; oxidative stress.

Publication types

Review

Abstract

Publication types

Grants and funding