α-Glucosidic hydroquinone derivatives from Viburnum erosum

Jinyoung Park; Jiho Lee; Hyeon Seok Jang; Birang Jeong; Seong Yeon Choi; Juyeol Kim; Yong Soo Kwon; Heejung Yang

doi:10.1016/j.phytochem.2021.112782

α-Glucosidic hydroquinone derivatives from Viburnum erosum

Phytochemistry. 2021 Jul:187:112782. doi: 10.1016/j.phytochem.2021.112782. Epub 2021 Apr 27.

Authors

Jinyoung Park¹, Jiho Lee¹, Hyeon Seok Jang¹, Birang Jeong¹, Seong Yeon Choi¹, Juyeol Kim¹, Yong Soo Kwon¹, Heejung Yang²

Affiliations

¹ College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
² College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea; Bionsight, Inc., Chuncheon, 24341, Republic of Korea. Electronic address: heejyang@kangwon.ac.kr.

PMID: 33915418
DOI: 10.1016/j.phytochem.2021.112782

Abstract

Six undescribed compounds (1-6) were isolated from the leaves of Viburnum erosum along with four known compounds 7-10. The structures were determined by NMR and MS spectroscopic analyses, and their absolute configurations were established by chemical and spectroscopic methods. Compounds 1-6 were α-glucosidic hydroquinone derivatives with different linear monoterpenoid structures. Compounds 1-10 were also evaluated for their tyrosinase inhibitory activities, and 10 showed potent inhibition of tyrosinase enzyme with IC₅₀ value of 37.9 μM compared to 47.6 μM of the positive control (β-arbutin).

Keywords: Tyrosinase inhibition; Viburnum erosum; β-arbutin.

MeSH terms

Arbutin / pharmacology
Glucosides
Hydroquinones / pharmacology
Monophenol Monooxygenase
Viburnum*

Substances

Glucosides
Hydroquinones
Arbutin
Monophenol Monooxygenase