Keys to Unlock the Enigma of Ocular Toxocariasis: A Systematic Review and Meta-analysis

Ocul Immunol Inflamm. 2021 Nov 17;29(7-8):1265-1276. doi: 10.1080/09273948.2021.1875007. Epub 2021 Apr 28.

Abstract

Purpose: Ocular toxocariasis (OT) is a zoonotic infection caused by larval stages of Toxocara canis and T. cati. The current review and meta-analysis aimed to evaluate the global prevalence of OT.

Methods: Five English (PubMed, Scopus, Science Direct, Web of Science, and Google Scholar) databases were explored and 101 articles met the inclusion criteria.

Results: The pooled prevalence (95% confidence interval) of OT was higher in immunological studies (9%. 6-12%) than in studies that applied ophthalmic examination (1%. 1-2%). The lower middle-income level countries had the highest prevalence (6%. 2-12%) as well as the African region (10%. 7-13%). The highest infection rate (4%. 2-7%) was detected in the 1-25 mean age group.

Conclusion: Regular anthelminthic treatment of cats and dogs, and removal of animal feces from public places must be considered.

Keywords: Toxocariasis; humans; ocular larva migrans; public health; zoonoses.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use
  • Cat Diseases / epidemiology
  • Cat Diseases / prevention & control
  • Cats
  • Dog Diseases / epidemiology
  • Dog Diseases / prevention & control
  • Dogs
  • Eye Infections, Parasitic / epidemiology*
  • Eye Infections, Parasitic / prevention & control
  • Eye Infections, Parasitic / veterinary
  • Humans
  • Toxocara canis
  • Toxocariasis / epidemiology*
  • Toxocariasis / prevention & control
  • Zoonoses / epidemiology*
  • Zoonoses / prevention & control

Substances

  • Anthelmintics