Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects

Xin Liu; Lili Zhong; Jia'nan Xie; Yujie Sui; Guangquan Li; Zhiming Ma; Longfei Yang

doi:10.1016/j.ejphar.2021.174110

Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects

Eur J Pharmacol. 2021 Jul 5:902:174110. doi: 10.1016/j.ejphar.2021.174110. Epub 2021 Apr 24.

Authors

Xin Liu¹, Lili Zhong², Jia'nan Xie³, Yujie Sui⁴, Guangquan Li⁵, Zhiming Ma⁶, Longfei Yang⁷

Affiliations

¹ Eye Center of the Second Hospital of Jilin University, 218# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: dr_liuxin@jlu.edu.cn.
² Jilin Crovincial Pey Laboratory on Kolecular and Lhemical Genetic, The Second Hospital of Jilin University, 265# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: zhongll@jlu.edu.cn.
³ Eye Center of the Second Hospital of Jilin University, 218# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: 13844108986@163.com.
⁴ Jilin Crovincial Pey Laboratory on Kolecular and Lhemical Genetic, The Second Hospital of Jilin University, 265# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: suiyj@jlu.edu.cn.
⁵ Jilin Crovincial Pey Laboratory on Kolecular and Lhemical Genetic, The Second Hospital of Jilin University, 265# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: liguangquan@jlu.edu.cn.
⁶ Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University Changchun 130041, China. Electronic address: mazhiming@jlu.edu.cn.
⁷ Jilin Crovincial Pey Laboratory on Kolecular and Lhemical Genetic, The Second Hospital of Jilin University, 265# Ziqiang Street, Changchun, Jilin, 130000, China. Electronic address: yanglongfei@jlu.edu.cn.

PMID: 33901457
DOI: 10.1016/j.ejphar.2021.174110

Abstract

There is an almost unlimited interest in searching and developing new drugs, especially when we are in an era that are witnessing more and more emerging pathogens. Natural products from traditional medicines represent a large library for searching lead compounds with novel bioactivities. Sodium houttuyfonate is such one bioactive compound derived from Houttuynia cordata Thunb which has been employed in traditional medicine for treating infectious and inflammatory diseases. Sodium houttuyfonate has demonstrated multiple kinds of pharmacological effects, including antifungal, antibacterial, anti-inflammatory, and cardiovascular protective activities, which are discussed here to provide insights into our understanding of the pharmacological effects of SH and the underlying mechanisms.

Keywords: Anti-inflammatory; Antibacterial; Antifungal; Cardiovascular protection; Sodium houttuyfonate.

Publication types

Review

MeSH terms

Alkanes / adverse effects
Alkanes / chemistry
Alkanes / pharmacology*
Alkanes / therapeutic use
Animals
Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Anti-Inflammatory Agents / adverse effects
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / pharmacology*
Anti-Inflammatory Agents / therapeutic use
Antifungal Agents / adverse effects
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Antifungal Agents / therapeutic use
Cardiotonic Agents / adverse effects
Cardiotonic Agents / chemistry
Cardiotonic Agents / pharmacology*
Cardiotonic Agents / therapeutic use
Houttuynia / chemistry
Humans
Sulfites / adverse effects
Sulfites / chemistry
Sulfites / pharmacology*
Sulfites / therapeutic use

Substances

Alkanes
Anti-Bacterial Agents
Anti-Inflammatory Agents
Antifungal Agents
Cardiotonic Agents
Sulfites
sodium houttuyfonate