Whole-Genome Sequencing of Shiga Toxin-Producing Escherichia coli OX18 from a Fatal Hemolytic Uremic Syndrome Case

Kenichi Lee; Atsushi Iguchi; Kazuhiro Uda; Sohshi Matsumura; Isao Miyairi; Kenji Ishikura; Makoto Ohnishi; Junji Seto; Kanako Ishikawa; Noriko Konishi; Hiromi Obata; Ichiro Furukawa; Hiromi Nagaoka; Hirotaka Morinushi; Natsuki Hama; Ryohei Nomoto; Hiroshi Nakajima; Hideaki Kariya; Mitsuhiro Hamasaki; Sunao Iyoda

doi:10.3201/eid2705.204162

Whole-Genome Sequencing of Shiga Toxin-Producing Escherichia coli OX18 from a Fatal Hemolytic Uremic Syndrome Case

Emerg Infect Dis. 2021 May;27(5):1509-1512. doi: 10.3201/eid2705.204162.

Abstract

We report a fatal case of hemolytic uremic syndrome with urinary tract infection in Japan caused by Shiga toxin-producing Escherichia coli. We genotypically identified the isolate as OX18:H2. Whole-genome sequencing revealed 3 potentially pathogenic lineages (OX18:H2, H19, and H34) that have been continuously isolated in Japan.

Keywords: Bacteria; E. coli; Japan; OX18; Og-typing; STEC; Shiga toxin–producing Escherichia coli; enteric infections; food safety; foodborne pathogens; whole-genome sequencing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli Infections*
Hemolytic-Uremic Syndrome*
Humans
Japan
Shiga-Toxigenic Escherichia coli* / genetics
Whole Genome Sequencing