The nuclear functions of long noncoding RNAs come into focus

Zhenxing Song; Jiamei Lin; Zhengguo Li; Chuan Huang

doi:10.1016/j.ncrna.2021.03.002

The nuclear functions of long noncoding RNAs come into focus

Noncoding RNA Res. 2021 Mar 27;6(2):70-79. doi: 10.1016/j.ncrna.2021.03.002. eCollection 2021 Jun.

Authors

Zhenxing Song^{1

2}, Jiamei Lin^{1

2}, Zhengguo Li^{1

2}, Chuan Huang^{1

2}

Affiliations

¹ School of Life Sciences, Chongqing University, Chongqing, 401331, China.
² Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, Chongqing, 401331, China.

Abstract

Long noncoding RNAs (lncRNAs), defined as untranslated and tightly-regulated transcripts with a length exceeding 200 nt, are common outputs of the eukaryotic genome. It is becoming increasingly apparent that many lncRNAs likely serve as important regulators in a variety of biological processes. In particular, some of them accumulate in the nucleus and function in diverse nuclear events, including chromatin remodeling, transcriptional regulation, RNA processing, DNA damage repair, etc. Here, we unite recent progresses on the functions of nuclear lncRNAs and provide insights into the future research directions of this field.

Keywords: Circular RNA; MALAT1; NEAT1; Nucleus; RNA-Binding protein; XIST.

Publication types

Review