Altered dynamic regional homogeneity in patients with conduct disorder

Abstract

Conduct disorder (CD) is a psychiatric condition characterized by severe aggressive and antisocial behaviors. Prior neuroimaging work reported that CD is associated with abnormal resting-state local intrinsic brain activity (IBA). However, few studies detected the time-varying brain activity patterns in CD. In this study, eighteen adolescent patients with CD and 18 typically developing controls underwent resting-state functional magnetic resonance imaging scans. We then compared the dynamic characteristics of IBA by calculating the dynamic regional homogeneity (dReHo) through a sliding-window approach between the two groups, and the correlations between the dReHo variability and clinical symptoms in CD were further examined. Moreover, the statistical between-group differences in dReHo were selected as classification features to help distinguish CD patients from controls by adopting a linear support vector machine (SVM) classifier. CD patients showed increased dReHo variability in the left precuneus, right postcentral gyrus, right precentral gyrus, left middle cingulate gyrus, and left paracentral lobule compared to controls, and dReHo variability in the left precuneus was significantly positively associated with impulsiveness scores in CD patients. Importantly, SVM combined with the leave-one-out cross-validation method results demonstrated that 75% (p < 0.001) subjects were correctly classified with sensitivity of 61% and specificity of 89%. Our results provided the initial evidence that CD is characterized by abnormal dynamic IBA patterns, giving novel insights into the neuropathological mechanisms of CD. Further, our findings exhibited that the dReHo variability may distinguish CD patients from controls with high accuracy.

Keywords: Conduct disorder; Dynamic regional homogeneity; Resting-state functional magnetic resonance imaging; Sliding-window; Support vector machine.