Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium

Merel Jacobs; Lies Lahousse; Hannelore P Van Eeckhoutte; Sara R A Wijnant; Joris R Delanghe; Guy G Brusselle; Ken R Bracke

doi:10.1183/23120541.00940-2020

Effect of ACE1 polymorphism rs1799752 on protein levels of ACE2, the SARS-CoV-2 entry receptor, in alveolar lung epithelium

ERJ Open Res. 2021 Apr 19;7(2):00940-2020. doi: 10.1183/23120541.00940-2020. eCollection 2021 Apr.

Authors

Merel Jacobs¹, Lies Lahousse², Hannelore P Van Eeckhoutte¹, Sara R A Wijnant^{1

2

3}, Joris R Delanghe⁴, Guy G Brusselle^{1

3

5}, Ken R Bracke¹

Affiliations

¹ Laboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
² Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
³ Dept of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
⁴ Laboratory of Clinical Chemistry, Dept of Diagnostic Sciences, Ghent University, Ghent, Belgium.
⁵ Dept of Respiratory Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

Increased protein levels of ACE2 in alveolar epithelium of subjects who are homozygous for the ACE1 insertion of rs1799752 might facilitate host cell entry of #SARSCoV2 and explain the higher prevalence of #COVID19 in certain regions https://bit.ly/3k6aAE8.