AGAP2-AS1 May Promote the Occurrence and Development of Glioblastoma by Sponging miR-9-5p: Evidence From a ceRNA Network

Xiaobin Luo; Tianqi Tu; Yali Zhong; Shangyi Xu; Xiangzhou Chen; Ligang Chen; Fubing Yang

doi:10.3389/fonc.2021.607989

AGAP2-AS1 May Promote the Occurrence and Development of Glioblastoma by Sponging miR-9-5p: Evidence From a ceRNA Network

Front Oncol. 2021 Apr 6:11:607989. doi: 10.3389/fonc.2021.607989. eCollection 2021.

Authors

Xiaobin Luo¹, Tianqi Tu¹, Yali Zhong², Shangyi Xu¹, Xiangzhou Chen¹, Ligang Chen^{1

3

4

5}, Fubing Yang^{1

3

4}

Affiliations

¹ Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
² Graduate School of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
³ Sichuan Clinical Research Center for Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
⁴ Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
⁵ Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Abstract

Glioblastoma (GBM), the primary malignant brain tumor, is typically associated with a poor prognosis and poor quality of life, mainly due to the lack of early diagnostic biomarkers and therapeutic targets. However, gene sequencing technologies and bioinformatics analysis are currently being actively utilized to explore potential targets for the diagnosis and management of malignancy. Herein, based on a variety of bioinformatics tools for the reverse prediction of target genes associated with the prognosis of GBM, a ceRNA network of AGAP2-AS1-miR-9-5p-MMP2/MMP9 was constructed, and a potential therapeutic target for GBM was identified. Enrichment analysis predicted that the ceRNA regulatory network participates in the processes of cell proliferation, differentiation, and migration.

Keywords: bioinformatics analysis; competing endogenous RNA; glioblastoma; lncRNA; miRNA; therapeutic targets.