Cell-specific drug targeting in the lung

Soumeya Abed; Rebecca Turner; Nickolas Serniuck; Victor Tat; Safaa Naiel; Aaron Hayat; Olivia Mekhael; Megan Vierhout; Kjetil Ask; Anthony F Rullo

doi:10.1016/j.bcp.2021.114577

Cell-specific drug targeting in the lung

Biochem Pharmacol. 2021 Aug:190:114577. doi: 10.1016/j.bcp.2021.114577. Epub 2021 Apr 19.

Authors

Affiliations

¹ Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.
² Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada.
³ Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada.
⁴ Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada. Electronic address: askkj@mcmaster.ca.
⁵ Department of Medicine, Firestone Institute for Respiratory Health, McMaster University, Hamilton, ON, Canada; Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada; Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, Canada. Electronic address: rulloa@mcmaster.ca.

PMID: 33887259
DOI: 10.1016/j.bcp.2021.114577

Abstract

Non-targeted drug delivery systems have several limitations including the decreased bioavailability of the drug, poor stability and rapid clearance in addition to off-target distribution. Cell-specific targeted delivery approaches promise to overcome some of these limitations and enhance therapeutic selectivity. In this review, we aim to discuss cell-specific targeted approachesin the lung at the biochemical and molecular levels. These approaches include;a) directly administered small molecule drugs with intracellular action; b) targeted biologics and synthetic hybrids with extracellular action; c) site activateddrugs; and d) delivery systems.We discuss the pharmaceutical and biochemical parameters that govern the fate of drug molecules at delivery sites while presenting an overview of relevant literature surrounding this area of research and current advancements.

Keywords: Biopolymers; Cell-specific; Drug release; Drug targeting; Immunotherapy; Lung; Nanocarriers; Pharmacokinetics; Site activated drugs.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / administration & dosage
Drug Carriers / administration & dosage
Drug Delivery Systems / methods*
Drug Delivery Systems / trends
Humans
Lung / cytology*
Lung / drug effects
Lung / physiology
Lung Diseases / drug therapy*
Lung Diseases / pathology*
Nanoparticles / administration & dosage
Respiratory Mucosa / cytology*
Respiratory Mucosa / drug effects
Respiratory Mucosa / physiology

Substances

Biocompatible Materials
Drug Carriers