Particulate Matter-Induced Cardiovascular Dysfunction: A Mechanistic Insight

Cardiovasc Toxicol. 2021 Jul;21(7):505-516. doi: 10.1007/s12012-021-09652-3. Epub 2021 Apr 22.

Abstract

Air pollution and particulate matter (PM) are significant factors for adverse health effects most prominently cardiovascular disease (CVD). PM is produced from various sources, which include both natural and anthropogenic. It is composed of biological components, organic compounds, minerals, and metals, which are responsible for inducing inflammation and adverse health effects. However, the adverse effects are related to PM size distribution. Finer particles are a significant cause of cardiovascular events. This review discusses the direct and indirect mechanisms of PM-induced CVD like myocardial infarction, the elevation of blood pressure, cardiac arrhythmias, atherosclerosis, and thrombosis. The two potential mechanisms are oxidative stress and systemic inflammation. Prenatal exposure has also been linked with cardiovascular outcomes later in life. Moreover, we also mentioned the epidemiological studies that strongly associate PM with CVD.

Keywords: Air pollution; Cardiac arrhythmia; Cardiac failure; Cardiovascular diseases; PM 2.5.

Publication types

  • Review

MeSH terms

  • Air Pollutants / adverse effects*
  • Air Pollution / adverse effects*
  • Animals
  • Cardiovascular Diseases / chemically induced*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular System / drug effects*
  • Cardiovascular System / metabolism
  • Cardiovascular System / physiopathology
  • Environmental Exposure / adverse effects*
  • Epigenesis, Genetic / drug effects
  • Humans
  • Inflammation Mediators / metabolism
  • Oxidative Stress / drug effects
  • Particle Size
  • Particulate Matter / adverse effects*
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Time Factors

Substances

  • Air Pollutants
  • Inflammation Mediators
  • Particulate Matter