The Ibuprofen-Cellulose nanofibril (IBU-CNF) drug delivery system was prepared by esterification of Ibuprofen (IBU) and cellulose nanofibril (CNF) with isopropyl acetate as the solvent and sulfuric acid as the catalyst. The results showed that IBU was successfully grafted on to the CNF molecular chain and the crystal structure of CNF did not change. Moreover, the natural three-dimensional network structure was maintained to a large extent. The maximum drug loading of IBU-CNF was 151.38 mg/g. In vitro drug release showed that IBU-CNF was pH-responsive and could be released continuously over 24 h. The cumulative release rate was approximately 90% under alkaline conditions but was low under acidic conditions. UV-visible spectra revealed that IBU retained its chemical activity after in vitro release.
Keywords: Cellulose nanofibril; Drug delivery systems; Esterification reaction; Ibuprofen; pH-responsive.
Copyright © 2021 Elsevier B.V. All rights reserved.