False-positive heparin-PF4 latex immunoturbidimetric assay due to lupus anti-coagulant interference: a case report

Br J Haematol. 2021 Jul;194(1):211-213. doi: 10.1111/bjh.17471. Epub 2021 Apr 20.

Authors

Hannah L McRae¹, Jozal W Moore², Jainulabdeen J Ifthikharuddin², Majed A Refaai¹

Affiliations

¹ Department of Pathology and Laboratory Medicine, Transfusion Medicine Division, Hemostasis and Thrombosis Unit, University of Rochester Medical Center, Rochester, NY, USA.
² Department of Medicine, Division of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY, USA.

PMID: 33878212
DOI: 10.1111/bjh.17471

No abstract available

Keywords: antiphospholipid syndrome; heparin; heparin induced thrombocytopenia; lupus anticoagulant; thrombocytopenia.

Publication types

Case Reports
Letter

MeSH terms

Antibodies, Antiphospholipid / blood*
Antiphospholipid Syndrome / blood
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / diagnosis
Antiphospholipid Syndrome / immunology
Artifacts*
Autoantigens / immunology*
Automation
Biopsy
Bone Marrow / pathology
Dexamethasone / pharmacology
Diagnosis, Differential
Dose-Response Relationship, Immunologic
False Positive Reactions
Heparin / adverse effects
Heparin / immunology*
Humans
Ischemic Stroke / etiology
Lupus Coagulation Inhibitor / blood*
Male
Middle Aged
Nephelometry and Turbidimetry / methods*
Platelet Factor 4 / immunology*
Status Epilepticus / etiology
Thrombocytopenia / blood*
Thrombocytopenia / chemically induced
Thrombocytopenia / diagnosis
Thrombocytopenia / immunology

Substances

Antibodies, Antiphospholipid
Autoantigens
Lupus Coagulation Inhibitor
Platelet Factor 4
Dexamethasone
Heparin