Multi-Dimensional Printing for Bone Tissue Engineering

Moyuan Qu; Canran Wang; Xingwu Zhou; Alberto Libanori; Xing Jiang; Weizhe Xu; Songsong Zhu; Qianming Chen; Wujin Sun; Ali Khademhosseini

doi:10.1002/adhm.202001986

Multi-Dimensional Printing for Bone Tissue Engineering

Adv Healthc Mater. 2021 Jun;10(11):e2001986. doi: 10.1002/adhm.202001986. Epub 2021 Apr 19.

Authors

Moyuan Qu^{1

2}, Canran Wang¹, Xingwu Zhou^{1

3}, Alberto Libanori¹, Xing Jiang^{1

4}, Weizhe Xu², Songsong Zhu⁵, Qianming Chen², Wujin Sun^{1

6}, Ali Khademhosseini^{1

3

6

7}

Affiliations

¹ Department of Bioengineering, Center for Minimally Invasive Therapeutics (C-MIT), California NanoSystems Institute, University of California, Los Angeles, CA, 90095, USA.
² Stomatology Hospital, School of Stomatology, School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Clinical Research Center of Oral Disease of Zhejiang Province, Zhejiang University, Hangzhou, Zhejiang, 310006, China.
³ Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.
⁴ School of Nursing, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
⁵ State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
⁶ Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
⁷ Jonsson Comprehensive Cancer Center, Department of Radiology, University of California, Los Angeles, CA, 90095, USA.

Abstract

The development of 3D printing has significantly advanced the field of bone tissue engineering by enabling the fabrication of scaffolds that faithfully recapitulate desired mechanical properties and architectures. In addition, computer-based manufacturing relying on patient-derived medical images permits the fabrication of customized modules in a patient-specific manner. In addition to conventional 3D fabrication, progress in materials engineering has led to the development of 4D printing, allowing time-sensitive interventions such as programed therapeutics delivery and modulable mechanical features. Therapeutic interventions established via multi-dimensional engineering are expected to enhance the development of personalized treatment in various fields, including bone tissue regeneration. Here, recent studies utilizing 3D printed systems for bone tissue regeneration are summarized and advances in 4D printed systems are highlighted. Challenges and perspectives for the future development of multi-dimensional printed systems toward personalized bone regeneration are also discussed.

Keywords: 3D printing; 4D printing; bone; drug delivery; tissue engineering.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Bone Regeneration
Bone and Bones
Humans
Printing, Three-Dimensional
Tissue Engineering*
Tissue Scaffolds*

Abstract

Publication types

MeSH terms

Grants and funding