Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma

Daniel Rickert; Jasmin Bartl; Daniel Picard; Flavia Bernardi; Nan Qin; Marta Lovino; Stéphanie Puget; Frauke-Dorothee Meyer; Idriss Mahoungou Koumba; Thomas Beez; Pascale Varlet; Christelle Dufour; Ute Fischer; Arndt Borkhardt; Guido Reifenberger; Olivier Ayrault; Marc Remke

doi:10.1007/s00401-021-02306-2

Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma

Acta Neuropathol. 2021 Jun;141(6):975-978. doi: 10.1007/s00401-021-02306-2. Epub 2021 Apr 17.

Authors

Daniel Rickert^#^{1

2

3

4}, Jasmin Bartl^#^{1

2

3

4}, Daniel Picard^{1

2

3

4}, Flavia Bernardi^{5

6}, Nan Qin^{1

2

3

4}, Marta Lovino⁷, Stéphanie Puget⁸, Frauke-Dorothee Meyer^{1

2

3

4}, Idriss Mahoungou Koumba^{2

3}, Thomas Beez⁹, Pascale Varlet¹⁰, Christelle Dufour^{11

12}, Ute Fischer^{2

3}, Arndt Borkhardt^{1

2

3}, Guido Reifenberger^{1

2

4}, Olivier Ayrault^#^{5

6}, Marc Remke^#^{13

14

15

16}

Affiliations

¹ Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
² German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany.
³ Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
⁴ Institute of Neuropathology, Düsseldorf and Medical Faculty, University Hospital, Heinrich Heine University, Düsseldorf, Germany.
⁵ Institut Curie, CNRS UMR, INSERM, PSL Research University, Orsay, France.
⁶ CNRS UMR 3347, INSERM U1021, Université Paris Sud, Université Paris-Saclay, Orsay, France.
⁷ Department of Control and Computer Engineering, DAUIN, Politecnico di Torino, Torino, Italy.
⁸ Department of Pediatric Neurosurgery, Necker Hospital, APHP, Université Paris Descartes, Paris, France.
⁹ Medical Faculty, Department of Neurosurgery, Heinrich Heine University, Düsseldorf, Germany.
¹⁰ Department of Neuropathology, GHU Paris-Neurosciences, Sainte-Anne Hospital, 75014, Paris, France.
¹¹ Department of Pediatric and Adolescent Oncology, Gustave Roussy, Villejuif, France.
¹² INSERM, Molecular Predictors and New Targets in Oncology, University Paris-Saclay, Villejuif, France.
¹³ Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. marc.remke@med.uni-duesseldorf.de.
¹⁴ German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf, Düsseldorf, Germany. marc.remke@med.uni-duesseldorf.de.
¹⁵ Department of Pediatric Oncology, Hematology, and Clinical Immunology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. marc.remke@med.uni-duesseldorf.de.
¹⁶ Institute of Neuropathology, Düsseldorf and Medical Faculty, University Hospital, Heinrich Heine University, Düsseldorf, Germany. marc.remke@med.uni-duesseldorf.de.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics*
Cerebellar Neoplasms* / classification
Cerebellar Neoplasms* / genetics
Cerebellar Neoplasms* / metabolism
DNA Methylation
Gene Expression Profiling
Gene Expression Regulation, Neoplastic*
Humans
Medulloblastoma / classification*
Medulloblastoma / genetics*
Medulloblastoma / metabolism
RNA, Circular / genetics*
Wnt Signaling Pathway*

Substances

Biomarkers, Tumor
RNA, Circular