Critical pertussis: A multi-centric analysis of risk factors and outcomes in Oman

Abstract

Objectives: To identify risk factors and outcomes of patients with critical pertussis.

Design: Retrospective observational cohort study.

Setting: Sultan Qaboos University Hospital and The Royal Hospital, Muscat, Oman.

Subjects: Children aged <13 years presenting to the emergency departments and diagnosed with laboratory-confirmed pertussis by polymerase chain reaction between January 2013 and December 2018.

Measurements and main results: In total, 157 patients were diagnosed with pertussis, of which 12% (n = 19) had critical pertussis. Patients with critical pertussis had a higher white blood cell count (WBCC) [adjusted odds ratio (aOR) 1.05; 95% confidence interval (CI) 1.02-1.08; P = 0.003], absolute lymphocyte count (ALC) (aOR 1.08; 95% CI 1.03-1.15; P = 0.004) and absolute neutrophil count (ANC) (aOR 1.05; 95% CI 1.01-1.10; P = 0.032) than patients with non-critical pertussis, even after multi-variate adjustment. The area under the curve for discriminatory accuracy of laboratory variables was 0.75 (95% CI 0.65-0.85), 0.74 (95% CI 0.64-0.84) and 0.72 (95% CI 0.60-0.83) for maximum WBCC, ALC and ANC, respectively, with Youden's cut-off values of 31.5 × 10⁹/L, 19.9 × 10⁹/L and 5.0 × 10⁹/L, respectively.

Conclusions: In children, higher WBCC, ALC and ANC were significant predictors of critical pertussis. A cut-off level of 31.5 × 10⁹/L for WBCC was associated with critical pertussis.

Keywords: Absolute neutrophil count; Critical pertussis; Leukocytosis.