Multimodal imaging of optic disc melanocytoma

Cinzia Mazzini; Giulio Vicini; Cristina Nicolosi; Giulia Pieretti; Stanislao Rizzo

doi:10.1177/11206721211010616

Multimodal imaging of optic disc melanocytoma

Eur J Ophthalmol. 2021 Apr 16:11206721211010616. doi: 10.1177/11206721211010616. Online ahead of print.

Authors

Cinzia Mazzini^{1

2}, Giulio Vicini^{1

2}, Cristina Nicolosi^{1

2}, Giulia Pieretti^{1

2}, Stanislao Rizzo^{3

4}

Affiliations

¹ Unit of Ocular Oncology, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.
² Eye Clinic, Neuromuscular and Sense Organs Department, Careggi University Hospital, Florence, Italy.
³ Ophthalmology Unit, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
⁴ Consiglio Nazionale della Ricerca (CNR), Pisa, Italy.

PMID: 33863247
DOI: 10.1177/11206721211010616

Abstract

Purpose: To describe the findings of four patients (four eyes) with optic disc melanocytoma (ODM), using multimodal imaging.

Methods: Retrospective case series.

Results: On ocular ultrasonography ODMs appeared as hyperechogenic lesions with moderate-to-high internal reflectivity. On blue-light fundus autofluorescence, ODMs showed total hypoautofluorescence, while, on infrared reflectance images appeared as bright and well-marginated lesions. MultiColor composite images showed reddish-brown lesions with well-defined margins. Swept-source optical coherence tomography revealed elevated lesions covering the optic disc with an irregular hyperreflective surface, dishomogeneous internal structure with hyperreflective dots, and posterior shadowing. In all cases optical coherence tomography angiography detected intratumoral blood vessels which were not detectable with fluorescein angiography.

Conclusion: Multimodal imaging in ODM might be useful both at presentation, increasing the diagnostic accuracy, and at follow-up, providing helpful details, that can help to rule out the possibility of malignant transformation and other ocular complications.

Keywords: MultiColor imaging; Optic disc melanocytoma; autofluorescence; multimodal imaging; optical coherence tomography; optical coherence tomography angiography.