Nature or nurture: Factors that influence bnAb development

Elise Landais; Devin Sok

doi:10.1016/j.chom.2021.03.013

Nature or nurture: Factors that influence bnAb development

Cell Host Microbe. 2021 Apr 14;29(4):540-542. doi: 10.1016/j.chom.2021.03.013.

Authors

Elise Landais¹, Devin Sok²

Affiliations

¹ IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: elandais@iavi.org.
² IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA; IAVI, New York, NY 10004, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: dsok@iavi.org.

PMID: 33857415
DOI: 10.1016/j.chom.2021.03.013

Abstract

The stochastic development of broadly neutralizing antibodies (bnAbs) to HIV-1 is influenced by complex viral and host interactions. In this issue of Cell Host & Microbe, Townsley et al. reveal that early B cell and virus interactions during acute infection are predictive for developing bnAb responses later in infection.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing
B-Lymphocytes
Broadly Neutralizing Antibodies
HIV Antibodies
HIV Infections*
HIV-1* / immunology
Humans
Viral Envelope

Substances

Antibodies, Neutralizing
Broadly Neutralizing Antibodies
HIV Antibodies