Abstract
Tumor DDR1 acts as a key factor during the desmoplastic response surrounding hepatic colorectal metastasis. Hepatic sinusoidal cell-derived soluble factors stimulate tumor DDR1 activation. DDR1 modulates matrix remodeling to promote metastasis in the liver through the interaction with hepatic stromal cells, specifically liver sinusoidal endothelial cells and hepatic stellate cells.
Keywords:
desmoplasia; discoidin domain receptor 1; hepatic stellate cells; liver metastasis from colorectal cancer; liver sinusoidal endothelial cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinoma / genetics*
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Carcinoma / metabolism
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Carcinoma / secondary
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Cell Line, Tumor
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Cell Proliferation
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Colon / metabolism
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Colon / pathology
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Colonic Neoplasms / genetics*
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Colonic Neoplasms / metabolism
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Colonic Neoplasms / pathology
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Discoidin Domain Receptor 1 / genetics*
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Discoidin Domain Receptor 1 / metabolism
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Hepatic Stellate Cells / pathology
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Humans
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Liver / metabolism
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Liver / pathology*
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Liver Neoplasms / genetics*
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Liver Neoplasms / metabolism
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Liver Neoplasms / secondary
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Male
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Mice
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Phosphorylation
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Prognosis
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Stromal Cells / metabolism
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Stromal Cells / pathology
Substances
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Discoidin Domain Receptor 1