H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Matteo Borro; Simone Negrini; Andrew Long; Sharon Chinthrajah; Giuseppe Murdaca

doi:10.1186/s12948-021-00143-y

H2-antagonist in IgE-mediated type I hypersensitivity reactions: what literature says so far?

Clin Mol Allergy. 2021 Apr 13;19(1):4. doi: 10.1186/s12948-021-00143-y.

Authors

Matteo Borro^{1

2

3}, Simone Negrini⁴, Andrew Long⁵, Sharon Chinthrajah⁵, Giuseppe Murdaca⁴

Affiliations

¹ Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy. borromatteo@libero.it.
² Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Grant Building, S093, 300 Pasteur Dr., Stanford, CA, 94305-5101, USA. borromatteo@libero.it.
³ Department of Internal Medicine, San Paolo Hospital, Via Genova 30 -, 17100, Savona, Italy. borromatteo@libero.it.
⁴ Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, 16132, Genoa, Italy.
⁵ Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Grant Building, S093, 300 Pasteur Dr., Stanford, CA, 94305-5101, USA.

Abstract

Histamine is a monoamine synthesized from the amino acid histidine that is well-known for its role in IgE-mediated anaphylaxis but has shown pleiotropic effects on the immune system, especially in order to promote inflammatory responses. H₁-receptor antagonist are common drugs used in mild/moderate allergic reactions whereas H₂-receptor antagonist are commonly administered in gastric ulcer but showed some properties in allergy too. The EAACI guidelines for diagnosis and treatment of anaphylactic reactions recommend their use as third-line therapy in adjunct to H₁-antagonists. The purpose of this article is to produce a complete summary of findings and evidence known so far about the usefulness of H₂-receptor antagonist in allergic reactons.

Keywords: Allergy; H2-receptor antagonist; Histamine; Type-I hypersensitivity reaction.

Publication types

Letter