Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient

Stem Cell Res. 2021 May:53:102325. doi: 10.1016/j.scr.2021.102325. Epub 2021 Apr 5.

Abstract

Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's disease patient carrying the T119I mutation in the PSEN1 gene. PSEN1 genotype was maintained and stemness and pluripotency confirmed in the FLENIi001-A hiPSC line.

MeSH terms

  • Aged
  • Alzheimer Disease* / genetics
  • Cell Differentiation
  • Fibroblasts
  • Humans
  • Induced Pluripotent Stem Cells*
  • Male
  • Presenilin-1 / genetics

Substances

  • PSEN1 protein, human
  • Presenilin-1