Neuropsychological effect of working memory capacity on mental rotation under hypoxia environment

Abstract

High-altitude exposure induces the decline of spatial manipulation such as mental rotation which is limited by working memory capacity, but the underlying neuropsychological effect remains to be identified. We evaluated the mental rotation task and the contralateral delay activity (CDA) task under hypoxia environment using the event-related potential. When compared with the controls, the behavior response was slowed on two tasks in the high-altitude group. The declined mental rotation and the decreased working memory capacity were synchronously related to the amplitudes of P50 and CDA, respectively. The P50 during mental rotation was positively correlated to that of rotation-related negativity (RRN) component, so was with the CDA. Time-frequency analysis showed that the beta/alpha power in mental rotation and the theta/alpha/beta power in CDA were enhanced in the high-altitude group. The present study might suggest that the decline of working memory capacity induced poor performance of mental rotation, which may be derived from a bottom-up sensory gating deficit reflected by P50.

Keywords: ERP; High altitude; Mental rotation; Sensory gating; Working memory capacity.