Synthesis and anti-tumor activity of marine alkaloids

Shiyang Zhou; Gangliang Huang; Guangying Chen

doi:10.1016/j.bmcl.2021.128009

Synthesis and anti-tumor activity of marine alkaloids

Bioorg Med Chem Lett. 2021 Jun 1:41:128009. doi: 10.1016/j.bmcl.2021.128009. Epub 2021 Apr 6.

Authors

Shiyang Zhou¹, Gangliang Huang², Guangying Chen³

Affiliations

¹ College of Chemistry, Chongqing Normal University, Chongqing 401331, China; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
² College of Chemistry, Chongqing Normal University, Chongqing 401331, China. Electronic address: huangdoctor226@163.com.
³ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.

PMID: 33831559
DOI: 10.1016/j.bmcl.2021.128009

Abstract

Marine alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure-activity relationship of various compounds were discussed.

Keywords: Anti-tumor activity; Marine alkaloid; Synthesis.

Publication types

Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Alkaloids / chemistry
Alkaloids / pharmacology*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / pathology

Substances

Alkaloids
Antineoplastic Agents