Generation of Bacterial Diversity by Segregation of DNA Strands

Vic Norris; Camille Ripoll

doi:10.3389/fmicb.2021.550856

Generation of Bacterial Diversity by Segregation of DNA Strands

Front Microbiol. 2021 Mar 22:12:550856. doi: 10.3389/fmicb.2021.550856. eCollection 2021.

Authors

Vic Norris¹, Camille Ripoll²

Affiliations

¹ Laboratory of Microbiology Signals and Microenvironment, Faculty of Science, University of Rouen, Mont Saint Aignan, France.
² Faculty of Science, University of Rouen, Mont Saint Aignan, France.

Abstract

The generation in a bacterial population of a diversity that is coherent with present and future environments is a fundamental problem. Here, we use modeling to investigate growth rate diversity. We show that the combination of (1) association of extended assemblies of macromolecules with the DNA strands and (2) the segregation of DNA strands during cell division allows cells to generate different patterns of growth rate diversity with little effect on the overall growth rate of the population and thereby constitutes an example of "order for free" on which evolution can act.

Keywords: assembly; bacteria; cell cycle; chromosome segregation; heterogeneity; hyperstructure; model.