Role of Extracellular Vesicles in Alzheimer's Disease: Current Advances

Abstract

The recent developments in the field of extracellular vesicles (EVs) point to their potential use for predicting and treating neurodegenerative diseases. This review focusses on the importance and latest advances in this field, especially with respect to Alzheimer's disease (AD). Increasing evidence shows that the progression of amyloidbeta and tau brain pathology is correlated to the cognitive decline associated with AD. Lot of experimental data suggests the involvement of EVs with these processes, for instance EVs are known to circulate the misfolded proteins involved in AD. The currently available information on the role of EVs in neurodegenerative disorder especially in AD have also presented the knowledge gaps on which future research efforts should be focused.

Keywords: Alzheimer’s disease; Aβ aggregation; Extracellular vesicles; biomarkers.; exosomes; neurodegeneration.