Numerical simulations on periprosthetic bone remodeling: a systematic review

Agostino Igor Mirulla; Salvatore Pinelli; Stefano Zaffagnini; Vincenzo Nigrelli; Tommaso Ingrassia; Stefano Di Paolo; Laura Bragonzoni

doi:10.1016/j.cmpb.2021.106072

Numerical simulations on periprosthetic bone remodeling: a systematic review

Comput Methods Programs Biomed. 2021 Jun:204:106072. doi: 10.1016/j.cmpb.2021.106072. Epub 2021 Mar 30.

Authors

Agostino Igor Mirulla¹, Salvatore Pinelli², Stefano Zaffagnini³, Vincenzo Nigrelli⁴, Tommaso Ingrassia⁴, Stefano Di Paolo⁵, Laura Bragonzoni⁶

Affiliations

¹ Department of Engineering, University of Palermo, Viale delle Scienze Ed.8, 90128 Palermo, Italy; Department of Biomedical and Neurmotor Sciences, University of Bologna, Via G. Pupilli 1, 40136 Bologna, Italy. Electronic address: agostino.mirulla@unibo.it.
² Department of Information Engineering, University of Pisa, Pisa, Via G. Caruso 16, 56122 Pisa, Italy.
³ Department of Biomedical and Neurmotor Sciences, University of Bologna, Via G. Pupilli 1, 40136 Bologna, Italy; 2nd Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via G. Pupilli 1, 40136 Bologna, Italy.
⁴ Department of Engineering, University of Palermo, Viale delle Scienze Ed.8, 90128 Palermo, Italy.
⁵ Department of Biomedical and Neurmotor Sciences, University of Bologna, Via G. Pupilli 1, 40136 Bologna, Italy.
⁶ Department for Life Quality Studies, University of Bologna, Corso d'Augusto 237, 47921 Rimini, Italy.

PMID: 33819822
DOI: 10.1016/j.cmpb.2021.106072

Abstract

Background and objective: The aim of the present study was to review the literature concerning the analysis of periprosthetic bone remodeling through finite element (FE) simulation.

Methods: A systematic review was conducted on 9 databases, taking into account a ten-year time period (from 2009 until 2020). The inclusion criteria were: articles published in English, publication date after 2009, full text articles, articles containing the keywords both in the abstract and in the title. The articles were classified through the following parameters: dimensionality of the simulation, modelling of the bone-prosthesis interface, output parameters, type of simulated prosthesis, bone remodeling algorithm.

Results: Sixty-seven articles were included in the study. Femur and tooth were the most evaluated bone segment (respectively 41.8% and 29.9%). The 55.2% of the evaluated articles used a bonded bone-prosthesis interface, 73% used 3D simulations, 67.2% of the articles (45 articles) evaluate the bone remodeling by the bone density variation. At last, 59.7% of the articles employed algorithms based on a specific remodeling function.

Conclusions: Increasing interest in the bone remodeling FE analysis in different bone segments emerged from the review, and heterogeneous solutions were adopted. An optimal balance between computational cost and accuracy is needed to accurately simulate the bone remodeling phenomenon in the post-operative period.

Keywords: Biological processes; Bone remodeling; Computational analysis; FE simulations; Prosthesis; Systematic review.

Publication types

Review
Systematic Review

MeSH terms

Bone Density
Bone Remodeling*
Computer Simulation
Femur* / diagnostic imaging
Femur* / surgery
Finite Element Analysis
Models, Biological