First case of abdominal infection caused by bacteroides fluxus

Anaerobe. 2021 Jun:69:102363. doi: 10.1016/j.anaerobe.2021.102363. Epub 2021 Apr 2.

Abstract

Bacteroides fluxus is a Gram-negative anaerobic bacillus isolated from human faeces in healthy individuals. Until now, this bacterium had not been involved in human diseases. We report the first case of abdominal infection due to this microorganism in an elderly patient. A 76-year-old man with a history of chronic pulmonary obstructive disease presented with dyspnea, orthopnea and cough. The clinical evolution worsened with both a colonic ischemia and further diffuse peritonitis of pancreatic origin. Peritoneal fluid was obtained and the culture yielded B. fluxus in pure culture. Resistance to penicillin, amoxicillin-clavulanate, clindamycin and moxifloxacin was documented. Treatment with meropenem + linezolid was started, but the patient finally died due to a multiorganic failure.

Keywords: Abdominal infection; Anaerobes; Bacteroides fluxus; Gene sequencing; MALDI TOF MS.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteroides / drug effects*
  • Bacteroides Infections / drug therapy*
  • Bacteroides Infections / mortality*
  • Fatal Outcome
  • Humans
  • Intraabdominal Infections / drug therapy*
  • Intraabdominal Infections / mortality*
  • Linezolid / therapeutic use*
  • Male
  • Meropenem / therapeutic use*
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Meropenem
  • Linezolid