Methicillin resistant staphylococci isolated in clinical samples: a 3-year retrospective study analysis

Abdel Karim Foloum; Luria Leslie Founou; Sabrina Karang; Yolande Maled; Cedrice Tsayem; Martin Kuete; Michel Noubom; Raspail Carrel Founou

doi:10.2144/fsoa-2020-0183

Methicillin resistant staphylococci isolated in clinical samples: a 3-year retrospective study analysis

Future Sci OA. 2021 Feb 4;7(4):FSO681. doi: 10.2144/fsoa-2020-0183.

Authors

Abdel Karim Foloum¹, Luria Leslie Founou^{2

3

4}, Sabrina Karang¹, Yolande Maled¹, Cedrice Tsayem⁵, Martin Kuete⁶, Michel Noubom^{7

8}, Raspail Carrel Founou^{3

7}

Affiliations

¹ Department of Biological Sciences, Higher Institute of Medical Technology, Yaoundé, Cameroon.
² Department of Food Safety & Environmental Microbiology, Centre of Expertise & Biological Diagnostic of Cameroon (CEDBCAM), Yaoundé, Cameroon.
³ AMR Insights, Ambassador Network.
⁴ Bioinformatics & Applied Machine Learning Research Unit, EDEN Foundation, Yaoundé, Cameroon.
⁵ Department of Clinical Biochemistry, Centre of Expertise & Biological Diagnostic of Cameroon (CEDBCAM), Yaoundé, Cameroon.
⁶ Department of Reproductive & Child Health, Centre of Expertise & Biological Diagnostic of Cameroon (CEDBCAM), Yaoundé, Cameroon.
⁷ Department of Biological Sciences, Faculty of Medicine & Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon.
⁸ District Hospital of Dschang, Dschang, Cameroon.

Abstract

Aim: To determine the prevalence and describe the antimicrobial resistance patterns of circulating methicillin-resistant staphylococci (MRS) isolated from clinical specimens during a 3-year period in Yaoundé, Cameroon.

Materials & methods: From January 2017 to December 2019, 1683 clinical samples were plated onto Mannitol salt agar. Bacterial identification was performed followed by antibiotic susceptibility testing. Data were analyzed using R program.

Results: Staphylococci were identified in 90 (5.35%) of the 1683 clinical samples. Among these, 83.33% were MRS with 78.67% being methicillin-resistant Staphylococcus aureus (MRSA). The prevalence of MRS infection increased significantly with age.

Conclusion: The study offers a good baseline for surveillance intervention to contain antimicrobial resistance and highlights the need to strengthen antimicrobial stewardship and infection, prevention and control programs in the country.

Keywords: Cameroon; MRSA; antimicrobial resistance; clinical samples; developing countries; methicillin resistant staphylococci; multi-drug resistance; sub-Saharan Africa.