Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system-current status and prospects

Curr Opin Colloid Interface Sci. 2021 Aug:54:101458. doi: 10.1016/j.cocis.2021.101458. Epub 2021 Mar 30.

Abstract

Nanoemulsions (NEs) of essential oil (EO) have significant potential to target microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and vaccines. Narrowing of drug discovery pipeline and the emergence of new viral diseases, especially, coronavirus disease, have created a niche to use NEs for augmenting currently available therapeutic options. Published literature demonstrated that EOs have an inherent broad spectrum of activity across bacterial, fungal, and viral pathogens. The emulsification process significantly improved the efficacy of the active ingredients in the EOs. This article highlights the research findings and patent developments in the last 2 years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV-2.

Keywords: Antiviral activity; Drug repurposing; Drug resistance; Drug-delivery; Microemulsion; Nanoemulsion; Vaccine delivery.

Publication types

  • Review