Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Yiben Huang; Jianing Wang; Jiamin Shen; Jiedong Ma; Xiaqi Miao; Keke Ding; Bingqian Jiang; Binbin Hu; Fangyi Fu; Lingzhi Huang; Meiying Cao; Xiaodiao Zhang

doi:10.2147/COPD.S292666

Relationship of Red Cell Index with the Severity of Chronic Obstructive Pulmonary Disease

Int J Chron Obstruct Pulmon Dis. 2021 Mar 26:16:825-834. doi: 10.2147/COPD.S292666. eCollection 2021.

Authors

Yiben Huang^#¹, Jianing Wang^#^{1

2}, Jiamin Shen^#^{1

2}, Jiedong Ma^{1

2}, Xiaqi Miao^{1

2}, Keke Ding^{1

2}, Bingqian Jiang^{1

2}, Binbin Hu^{1

2}, Fangyi Fu^{1

2}, Lingzhi Huang¹, Meiying Cao³, Xiaodiao Zhang¹

Affiliations

¹ Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.
² School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, People's Republic of China.
³ Department of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.

^# Contributed equally.

Abstract

Background: We aimed to investigate the association between red cell index (RCI) and the severity of Chronic Obstructive Pulmonary Disease (COPD), and compare predictive value of RCI, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) for the severity of COPD.

Methods: A total of 207 participants were recruited (100 COPD patients and 107 healthy controls). COPD patients were divided into two groups according to the optimal cut-off value of RCI determined by the receiver operating characteristic (ROC) curve. Pearson's correlation test, logistic regression analysis and other tests were performed.

Results: Compared with low RCI group, the forced expiration volume in 1 second (FEV₁) and FEV₁ in percent of the predicted value (FEV₁%) in high RCI group were lower (p = 0.016, p = 0.001). There was a negative correlation between RCI and FEV₁% (r = -0.302, p = 0.004), while no correlation between FEV₁% and NLR as well as PLR were found. RCI showed higher predictive value than NLR and PLR for predicting Global Initiative for Chronic Obstructive Lung Disease classification (GOLD), with a cut-off value of 1.75 and area under the curve (AUC) of 0.729 (p = 0.001). Multivariate logistic regression analysis proved that RCI was an independent factor for lung function in COPD patients (odds ratio [OR] = 4.27, 95% CI: 1.57-11.63, p = 0.004).

Conclusion: RCI is a novel biomarker that can better assess pulmonary function and severity of COPD than NLR and PLR. Higher RCI is related to deterioration of pulmonary function.

Keywords: COPD; RCI; biomarker; pulmonary function.

MeSH terms

Erythrocyte Indices
Forced Expiratory Volume
Humans
Lymphocytes
Neutrophils
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive* / diagnosis
Retrospective Studies

Grants and funding

This work was funded by the Wenzhou Municipal Sci-Tech Bureau Program (grant number Y20180365). The Funding body had no role in the design of the study, data collection, interpretation of data, statistical analysis or the draft of the manuscript.