A Case of EBV-Negative Aggressive NK-cell Leukemia: Use of Next-Generation Sequencing in Demystifying a Diagnostic Dilemma and Guiding Clinical Care

Clin Lymphoma Myeloma Leuk. 2021 Jul;21(7):e583-e587. doi: 10.1016/j.clml.2021.02.010. Epub 2021 Feb 27.

Authors

Vanessa E Kennedy¹, Roberto Ruiz-Cordero², Diwash Jangam³, Kwun Wah Wen², Neil Dunavin⁴, Robert S Ohgami², Parul Bhargava², Weiyun Ai⁴, Bita Fakhri⁴

Affiliations

¹ Department of Medicine, University of California, San Francisco, CA. Electronic address: vanessa.kennedy@ucsf.edu.
² Department of Pathology, University of California, San Francisco, CA.
³ Department of Pathology, Stanford University, Stanford, CA.
⁴ Department of Medicine, University of California, San Francisco, CA.

PMID: 33814335
DOI: 10.1016/j.clml.2021.02.010

No abstract available

Keywords: ANKL; Natural Killer cell; PEG-asparaginase-based regimen; digital pathology imaging analysis; viral DNA in NGS.

Publication types

Case Reports

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Biomarkers, Tumor / genetics*
Biopsy
Bone Marrow / pathology
DNA Mutational Analysis
Diagnosis, Differential
Herpesvirus 4, Human / isolation & purification
High-Throughput Nucleotide Sequencing
Humans
Leukemia, Large Granular Lymphocytic / diagnosis*
Leukemia, Large Granular Lymphocytic / genetics
Leukemia, Large Granular Lymphocytic / pathology
Lymphoma, Extranodal NK-T-Cell / diagnosis
Lymphoma, Extranodal NK-T-Cell / genetics
Male
Middle Aged
Skin / pathology
Skin Neoplasms / diagnosis*
Skin Neoplasms / genetics
Skin Neoplasms / pathology
Tumor Necrosis Factor alpha-Induced Protein 3 / genetics

Substances

Biomarkers, Tumor
TNFAIP3 protein, human
Tumor Necrosis Factor alpha-Induced Protein 3