Implementation of dose point kernel (DPK) for dose optimization of 177Lu/90Y cocktail radionuclides in internal dosimetry

Abstract

Background: Due to the importance of choosing the applicable dosimetry method in radionuclide therapy, the present study was conducted to investigate the efficiency of the implementation of Dose Point Kernel (DPK) for dose optimization of ¹⁷⁷Lu/⁹⁰Y Cocktail Radionuclides in internal Dosimetry.

Methods: In this study, simulations and calculations of DPK were performed using the GATE/GEANT4 Monte Carlo code. For specific liver dosimetry, the NCAT phantom and convolution algorithm-based Fast Fourier Transform method was used by MATLAB software.

Results: The self-dose of ¹⁷⁷Lu and ⁹⁰Y radionuclides in the liver of NCAT phantom were 1.1708E-13, and 4.8420E-11 (Gy/Bq), respectively, and the cross-dose of ¹⁷⁷Lu and ⁹⁰Y radionuclides out of the liver of NCAT phantom were 2.03615E-16, and 0.8422E-13 (Gy/Bq) respectively. Overall results showed that with an increase the value of ⁹⁰Y with quarter steps in a cocktail, the amount of the self-dose increase 1.5, 6, and 29 times respectively, and with an increase the value of ¹⁷⁷Lu in quarter step in a cocktail, the amount of the cross dose decrease 3, 15 and 68 percent respectively.

Conclusion: Generally, the present results indicate that the calculated DPK functions of ¹⁷⁷Lu and ⁹⁰Y cocktails can play an important role in choosing the best combination of radionuclide to optimize treatment planning in cocktail radionuclide therapy.

Keywords: (177)Lu/(90)Y; Cocktail radionuclides; Dose point kernel; Internal dosimetry.