Abstract
Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. The purpose of this review is to comprehensively present the past and current research on fenamates in the context of neurodegenerative diseases with a special emphasis on tolfenamic acid and Alzheimer's disease. Furthermore, this review discusses the major molecular pathways modulated by fenamates.
Keywords:
Alzheimer’s disease; NSAID; fenamate; flufenamic acid; meclofenamic acid; mefenamic acid; neurodegenerative; tolfenamic acid.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Fenamates / adverse effects
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Fenamates / pharmacokinetics
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Fenamates / therapeutic use*
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Humans
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Nerve Degeneration*
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Neurodegenerative Diseases / drug therapy*
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology
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Neurons / drug effects*
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Neurons / metabolism
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Neurons / pathology
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Neuroprotective Agents / adverse effects
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Neuroprotective Agents / pharmacokinetics
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Neuroprotective Agents / therapeutic use*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Fenamates
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Neuroprotective Agents