A review on synthesis and biological activities of D-ring modified pregnenolone

Arfeen Iqbal; Tabassum Siddiqui

doi:10.1016/j.steroids.2021.108827

A review on synthesis and biological activities of D-ring modified pregnenolone

Steroids. 2021 Jun:170:108827. doi: 10.1016/j.steroids.2021.108827. Epub 2021 Mar 29.

Authors

Arfeen Iqbal¹, Tabassum Siddiqui²

Affiliations

¹ Department of Chemistry, Aligarh Muslim University, Aligarh, UP 202002, India.
² Department of Chemistry, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address: tabassum07chemistry@gmail.com.

PMID: 33794281
DOI: 10.1016/j.steroids.2021.108827

Abstract

Steroids are polycyclic compounds and are broadly exist in the natural world and display various biological activities. Many steroidal compounds have been used as traditional medicines, for example, antibacterial and few as hormone like medication. The introduction of heterocycle or heteroatom in the steroidal moiety has a significant biological impact. These derivatives have widespread biological activities such as anticancer, anti-inflammatory, anti-ulcer and antimicrobial. The present article is a brief review of the recent development of synthesis and biological activities of pregnenolone derivatives.

Keywords: Anti-cancer; Heterocycles; Pregnenolone; Steroids.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antineoplastic Agents
Pregnenolone*
Steroids*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Steroids
Pregnenolone