Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD)

Alzheimers Dement. 2021 Oct;17(10):1675-1686. doi: 10.1002/alz.12334. Epub 2021 Apr 1.

Abstract

Introduction: The National Institute on Aging Alzheimer's Disease Research Center program added the Lewy body dementia module (LBD-MOD) to the Uniform Data Set to facilitate LBD characterization and distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). We tested the performance of the LBD-MOD.

Methods: The LBD-MOD was completed in a single-site study in 342 participants: 53 controls, 78 AD, and 110 DLB; 79 mild cognitive impairment due to AD (MCI-AD); and 22 MCI-DLB.

Results: DLB differed from AD in extrapyramidal symptoms, hallucinations, apathy, autonomic features, REM sleep behaviors, daytime sleepiness, cognitive fluctuations, timed attention tasks, and visual perception. MCI-DLB differed from MCI-AD in extrapyramidal features, mood, autonomic features, fluctuations, timed attention tasks, and visual perception. Descriptive data on LBD-MOD measures are provided for reference.

Discussion: The LBD-MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI-DLB.

Keywords: Alzheimer's Disease Center program; Alzheimer's disease; DLB; Lewy body composite risk score; dementia; dementia with Lewy bodies; mild cognitive impairment; module; uniform data set.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis
  • Cognitive Dysfunction / diagnosis*
  • Cross-Sectional Studies
  • Diagnosis, Differential*
  • Female
  • Humans
  • Lewy Body Disease / diagnosis*
  • Male
  • Neuropsychological Tests
  • Parkinsonian Disorders / etiology
  • REM Sleep Behavior Disorder / etiology