mSphere of Influence: Viruses-Pathogens or Expert Cell Biologists?

mSphere. 2021 Mar 31;6(2):e00241-21. doi: 10.1128/mSphere.00241-21.

Abstract

Chelsey C. Spriggs works in the field of DNA viral entry with a specific interest in virus-host interactions. In this mSphere of Influence article, she reflects on how two papers, "The HCMV assembly compartment is a dynamic Golgi-derived MTOC that controls nuclear rotation and virus spread" (D. J. Procter, A. Banerjee, M. Nukui, K. Kruse, et al., Dev Cell 45:83-100.e7, 2018, https://doi.org/10.1016/j.devcel.2018.03.010) and "Cytoplasmic control of intranuclear polarity by human cytomegalovirus" (D. J. Procter, C. Furey, A. G. Garza-Gongora, S. T. Kosak, D. Walsh, Nature 587:109-114, 2020, https://doi.org/10.1038/s41586-020-2714-x), impacted her research by reinforcing the scientific value in using viruses to understand cell biology.

Keywords: HCMV; host-pathogen interactions; virus.

MeSH terms

  • COVID-19
  • Cell Biology*
  • Cytopathogenic Effect, Viral
  • Host Microbial Interactions*
  • Humans
  • Viruses / pathogenicity*