Precocious clonal hematopoiesis in Down syndrome is accompanied by immune dysregulation

Blood Adv. 2021 Apr 13;5(7):1791-1796. doi: 10.1182/bloodadvances.2020003858.

Abstract

  1. Children with Down syndrome develop early signs of clonal evolution that resemble traditional clonal hematopoiesis.

  2. Children with trisomy 21 who exhibit clonal hematopoiesis display cytokine and gene expression profiles indicative of disrupted immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clonal Evolution
  • Clonal Hematopoiesis*
  • Down Syndrome* / complications
  • Down Syndrome* / genetics
  • Hematopoiesis / genetics
  • Humans