Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca²⁺ homeostasis in diabetic cataract

Clin Transl Med. 2021 Mar;11(3):e327. doi: 10.1002/ctm2.327.

Authors

Yong Wang¹, Suwen Bai², Ru Zhang¹, Lin Xia¹, Linghui Chen¹, Jizheng Guo², Fang Dai³, Juan Du², Bing Shen²

Affiliations

¹ Department of Ophthalmology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
² Department of Physiology, School of Basic Medicine, Anhui Medical University, Hefei, China.
³ Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Calcium Channels / genetics
Calcium Channels / metabolism*
Cataract / etiology
Cataract / genetics*
Cataract / metabolism
Diabetes Complications / genetics*
Diabetes Complications / metabolism
Disease Models, Animal
Epithelial Cells / metabolism*
Homeostasis / genetics
Lens, Crystalline / metabolism*
Rats
Rats, Sprague-Dawley

Substances

Calcium Channels
Orai3 protein, rat