CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Shaotao Jiang; Rongdang Fu; Jiewei Shi; Huijie Wu; Jialuo Mai; Xuefeng Hua; Huan Chen; Jie Liu; Minqiang Lu; Ning Li

doi:10.3389/fonc.2021.553706

CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology

Front Oncol. 2021 Mar 10:11:553706. doi: 10.3389/fonc.2021.553706. eCollection 2021.

Authors

Shaotao Jiang¹, Rongdang Fu², Jiewei Shi³, Huijie Wu⁴, Jialuo Mai¹, Xuefeng Hua¹, Huan Chen¹, Jie Liu¹, Minqiang Lu¹, Ning Li¹

Affiliations

¹ Department of HBP SURGERY II, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
² Department of Hepatic Surgery, The First People's Hospital of Foshan, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, China.
³ Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
⁴ Department of Obstetrics, The First People's Hospital of Foshan, Affiliated Foshan Hospital of Sun Yat-sen University, Foshan, China.

Abstract

Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5'-cap or a 3'-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.

Keywords: VEGF; circRNA; miRNA; signaling pathways; tumor angiogenesis.

Publication types

Review