Changes in Intraocular Pressure after Transepithelial Photorefractive Keratectomy and Femtosecond Laser In Situ Keratomileusis

Chien-Chih Chou; Po-Jen Shih; Hung-Chou Lin; Jun-Peng Chen; Jia-Yush Yen; I-Jong Wang

doi:10.1155/2021/5592195

Changes in Intraocular Pressure after Transepithelial Photorefractive Keratectomy and Femtosecond Laser In Situ Keratomileusis

J Ophthalmol. 2021 Mar 10:2021:5592195. doi: 10.1155/2021/5592195. eCollection 2021.

Authors

Chien-Chih Chou^{1

2}, Po-Jen Shih³, Hung-Chou Lin⁴, Jun-Peng Chen⁵, Jia-Yush Yen⁶, I-Jong Wang⁷

Affiliations

¹ Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan.
² Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
³ Department of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
⁴ Dr. Lin's Eye Clinic and Laser Vision Correction Center, Taoyuan, Taiwan.
⁵ Biostatistics Task Force of Taichung Veterans General Hospital, Taichung, Taiwan.
⁶ Department of Mechanical Engineering, National Taiwan University, Taipei, Taiwan.
⁷ Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Abstract

Purpose: To investigate the changes in intraocular pressure (IOP) and biomechanically corrected IOP (bIOP) in patients undergoing transepithelial photorefractive keratectomy (TPRK) and femtosecond laser in situ keratomileusis (FS-LASIK) and to determine the effects of preoperative biomechanical factors on IOP and bIOP changes after FS-LASIK and TPRK.

Design: A retrospective comparative study.

Methods: We retrospectively investigated the IOP and corneal biomechanical changes in 93 eyes undergoing FS-LASIK and 104 eyes undergoing TPRK in a clinical setting. Preoperative and postoperative data on ophthalmic and Corvis ST examinations, in vivo Young's modulus, and noncontact tonometry were analyzed. Marginal linear regression models with generalized estimating equations were used for intragroup and intergroup comparisons of IOP and bIOP changes.

Results: In the univariate model, IOP reduction after FS-LASIK was 2.49 mmHg higher than that after TPRK. In addition, bIOP reduction after FS-LASIK was 1.85 mmHg higher than that after TPRK. In the multiple regression model, we revealed that IOP reduction after FS-LASIK was 1.75 mmHg higher than that after TPRK. Additionally, bIOP reduction after FS-LASIK was 1.64 mmHg higher than that after TPRK. Postoperative changes in bIOP were less than those in IOP. In addition, Young's modulus and CBI had no significant effect on postoperative IOP and bIOP changes. We establish a biomechanically predictive model using the available data to predict postoperative IOP and bIOP changes after TPRK and FS-LASIK.

Conclusions: Reductions in IOP and bIOP after FS-LASIK were 1.75 mmHg and 1.64 mmHg, respectively, more than those after TPRK, after adjustment for confounders. We revealed that the type of refractive surgery and peak distance (PD) were significant predictors of postoperative IOP and bIOP changes. By contrast, depth of ablation showed a significant effect on only IOP changes.