miR-22-3p/PGC1 β Suppresses Breast Cancer Cell Tumorigenesis via PPAR γ

Xuehui Wang; Zhilu Yao; Lin Fang

doi:10.1155/2021/6661828

miR-22-3p/PGC1 β Suppresses Breast Cancer Cell Tumorigenesis via PPAR γ

PPAR Res. 2021 Mar 12:2021:6661828. doi: 10.1155/2021/6661828. eCollection 2021.

Authors

Xuehui Wang^{1

2}, Zhilu Yao^{1

2}, Lin Fang^{1

2}

Affiliations

¹ Department of Thyroid and Breast Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
² Nanjing Medical University, Nanjing 211166, China.

Abstract

In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1β and finally regulate the PPARγ pathway in BC. In conclusion, miR-22-3p/PGC1β suppresses BC cell tumorigenesis via PPARγ, which may become a potential biomarker and therapeutic target.