Energy absorption of human red blood cells and conductivity of the cytoplasm influenced by temperature

Abstract

The energy absorbed into tissues is known as the specific energy absorption (SAR) which is dependent on conductivity of the tissue. We calculated cytoplasmic conductivity of human red blood cell (HRBC) using the intracellular ionic concentrations and the Debye-Hückel-Onsager relation. The overall concentration is determined by cell volume and cell water content. The calculated HRBC conductivity at 25 ^o C was σ_c,₂₅ = 0.5566 ± 0.0146 S m^-1, ±SE). It is exponentially related to temperature: Q₁₀ ≈ 1.866. At 37 ^o C, the calculated SAR value is 1.6 W kg^-1 using a linear temperature compensation of conductivity. However, if using a biologically realistic non-linear temperature compensated conductivity, the SAR is ≈ 2.62 ± 0.05 W kg^-1. The relationship between SAR and temperature increase is not straightforward. Since there is a wide variance in cellular ionic and water perfusion rates more tissue-specific SAR limits which consider temperature-related factors would be valuable.

Keywords: Cell volume; Electrical conductivity; Human red blood cells, HRBC; Q10; Specific energy absorption (SAR); Temperature dependence.