Recent advances in guar gum based drug delivery systems and their administrative routes

Int J Biol Macromol. 2021 Jun 30:181:653-671. doi: 10.1016/j.ijbiomac.2021.03.087. Epub 2021 Mar 22.

Abstract

Guar gum-based drug carrier systems have gained attention for the delivery of various therapeutic agents via different administration routes for attaining controlled and sustained release. Guar gum offers a safe and effective system for drug delivery due to its natural occurrence, easy availability, biocompatibility, and biodegradability, besides simple and mild preparation techniques. Furthermore, the possibility of using various routes such as oral, buccal, transdermal, intravenous, and gene delivery further diversify guar gum applications in the biomedical field. This review delineates the recent investigation on guar gum-based drug carrier systems like hydrogels, nanoparticles, nanocomposites, and scaffolds along with their related delivery routes. Also, the inclusion of data of the loading and subsequent release of the drugs enables to explore the noble and improved drug targeting therapies.

Keywords: Administrative routes; Drug delivery potential; Guar gum.

Publication types

  • Review

MeSH terms

  • Drug Administration Routes
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Galactans / administration & dosage*
  • Galactans / chemistry*
  • Gene Transfer Techniques
  • Mannans / administration & dosage*
  • Mannans / chemistry*
  • Nanoparticles / chemistry
  • Plant Gums / administration & dosage*
  • Plant Gums / chemistry*

Substances

  • Drug Carriers
  • Galactans
  • Mannans
  • Plant Gums
  • guar gum