Designing active mats based on cellulose acetate/polycaprolactone core/shell structures with different release kinetics

Adrián Rojas; Eliezer Velásquez; Constanza Piña; María José Galotto; Carol López de Dicastillo

doi:10.1016/j.carbpol.2021.117849

Designing active mats based on cellulose acetate/polycaprolactone core/shell structures with different release kinetics

Carbohydr Polym. 2021 Jun 1:261:117849. doi: 10.1016/j.carbpol.2021.117849. Epub 2021 Feb 24.

Authors

Adrián Rojas¹, Eliezer Velásquez², Constanza Piña³, María José Galotto⁴, Carol López de Dicastillo⁵

Affiliations

¹ University of Santiago of Chile (USACH), Packaging Innovation Center (LABEN-Chile), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170201, Santiago, Chile. Electronic address: adrian.rojass@usach.cl.
² University of Santiago of Chile (USACH), Packaging Innovation Center (LABEN-Chile), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170201, Santiago, Chile. Electronic address: eliezer.velasquez@usach.cl.
³ University of Santiago of Chile (USACH), Packaging Innovation Center (LABEN-Chile), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170201, Santiago, Chile. Electronic address: constanza.pina@usach.cl.
⁴ University of Santiago of Chile (USACH), Packaging Innovation Center (LABEN-Chile), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Technological Faculty, Food Science and Technology Department, 9170201, Santiago, Chile. Electronic address: maria.galotto@usach.cl.
⁵ University of Santiago of Chile (USACH), Packaging Innovation Center (LABEN-Chile), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Center for the Development of Nanoscience and Nanotechnology (CEDENNA), 9170201, Santiago, Chile; University of Santiago of Chile (USACH), Technological Faculty, Food Science and Technology Department, 9170201, Santiago, Chile. Electronic address: analopez.dediscastillo@usach.cl.

PMID: 33766345
DOI: 10.1016/j.carbpol.2021.117849

Abstract

Core/shell electrospun mats based on cellulose acetate (CA) and polycaprolactone (PCL) were developed as novel active materials for releasing quercetin (Quer) and curcumin (Cur). The effect of polymeric uniaxial and coaxial electrospun systems and the chemical structures of Quer and Cur on the structural, thermal, and mass transfer properties of the developed mats were investigated. Release modelling indicated that the diffusion of the active agents from the uniaxial PCL fibers was highly dependent on the type of food simulant. Higher diffusion coefficients were obtained for both active agents in acid food simulant due to the higher swelling of the electrospun mats. In addition, CA/PCL coaxial structures slowed down the diffusion of both active agents into both food simulants. CA increased the retention of the active compounds in the polymer structure, resulting in partition coefficients values higher than the values obtained for uniaxial active PCL mats.

Keywords: Cellulose acetate; Cellulose acetate (CA) PubChem CID 139600838; Chloroform PubChem CID 10176135; Core/shell Structure; Curcumin (Cur) PubChem CID 969516; Electrospinning; Kinetic release; N,N-Dimethylformamide (DMF) PubChem CID 16213592; Quercetin (Quer) PubChem CID 5280343.