Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial

Hadi Bazyar; Ahmad Zare Javid; Hossein Bavi Behbahani; Fardin Moradi; Bahman Moradi Poode; Parichehr Amiri

doi:10.1186/s13063-021-05174-z

Consumption of melatonin supplement improves cardiovascular disease risk factors and anthropometric indices in type 2 diabetes mellitus patients: a double-blind, randomized, placebo-controlled trial

Trials. 2021 Mar 25;22(1):231. doi: 10.1186/s13063-021-05174-z.

Authors

Hadi Bazyar^{1

2}, Ahmad Zare Javid², Hossein Bavi Behbahani¹, Fardin Moradi³, Bahman Moradi Poode¹, Parichehr Amiri⁴

Affiliations

¹ Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. amiriparichehr70@gmail.com.

Abstract

Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).

Materials and methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for 8 weeks. Systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHtR) were evaluated in all the patients pre- and post-intervention.

Results: Melatonin supplementation for 8 weeks significantly decreased the mean levels of SBP, MAP, PP, weight, BMI, WC, HC, BAI, AVI, conicity index, and WHtR post-intervention (p < 0.05). Also, the median changes of SBP, MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p < 0.05). A significant increase (p < 0.001) was observed in the mean levels of ABSI in the intervention group. The median changes of ABSI were significantly greater in the intervention group compared with the control group (p < 0.001).

Conclusions: Consumption of melatonin supplement may be effective in controlling arterial pressure including SBP, MAP, and PP and anthropometric indices (as predictors of obesity) in T2DM patients.

Trial registration: Iranian Registry of Clinical Trials IRCT20190303042905N1 . Registered on 17 May 2019.

Keywords: Blood pressure; Melatonin; New anthropometric indices; Type 2 diabetes mellitus.

Publication types

Randomized Controlled Trial

MeSH terms

Body Mass Index
Cardiovascular Diseases* / diagnosis
Cardiovascular Diseases* / etiology
Cardiovascular Diseases* / prevention & control
Cross-Sectional Studies
Diabetes Mellitus, Type 2* / diagnosis
Diabetes Mellitus, Type 2* / drug therapy
Dietary Supplements
Humans
Iran
Melatonin* / therapeutic use
Risk Factors
Waist Circumference

Substances

Melatonin

Grants and funding

97S43/Ahvaz Jundishapur University of Medical Sciences