Four unsaturated fatty acid derivatives including three new pantheric acids (1-3), together with three known polyketides (5-7), were isolated from a culture broth of the marine-derived fungus Aspergillus sp. SCAU150. Their complete structures were determined by NMR and HRESIMS data analyses. The antifungal activity of the isolated compounds above was evaluated and 2 was found to show moderated activity toward the phytopathogenic fungus Fusarium solani bio-80814 with an inhibition zone diameter of 6 mm under 5 µg/disc.
Keywords: Aspergillus; Marine-derived fungus; antifungal activity; fatty acid.