Admission Dehydration Is Associated With Significantly Lower In-Hospital Mortality After Intracerebral Hemorrhage

Bin Gao; Hongqiu Gu; Wengui Yu; Shimeng Liu; Qi Zhou; Kaijiang Kang; Jia Zhang; Zixiao Li; Xingquan Zhao; Yongjun Wang

doi:10.3389/fneur.2021.637001

Admission Dehydration Is Associated With Significantly Lower In-Hospital Mortality After Intracerebral Hemorrhage

Front Neurol. 2021 Mar 8:12:637001. doi: 10.3389/fneur.2021.637001. eCollection 2021.

Authors

Bin Gao^{1

2}, Hongqiu Gu², Wengui Yu³, Shimeng Liu^{1

2}, Qi Zhou², Kaijiang Kang^{1

2}, Jia Zhang^{1

2}, Zixiao Li^{1

2}, Xingquan Zhao^{1

2

4}, Yongjun Wang^{1

2}

Affiliations

¹ Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
² China National Clinical Research Center for Neurological Diseases, Beijing, China.
³ Department of Neurology, University of California, Irvine, Irvine, CA, United States.
⁴ Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China.

Abstract

Background and Purpose: Our aim was to investigate the frequency of dehydration at admission and associations with in-hospital mortality in patients with intracerebral hemorrhage (ICH). Methods: Data of consecutive patients with ICH between August 2015 and July 2019 from the China Stroke Center Alliance (CSCA) registry were analyzed. The patients were stratified based on the blood urea nitrogen (BUN) to creatinine (CR) ratio (BUN/CR) on admission into dehydrated (BUN/CR ≥ 15) or non-dehydrated (BUN/CR < 15) groups. Data were analyzed with multivariate logistic regression models to investigate admission dehydration status and the risks of death at hospital. Results: A total number of 84,043 patients with ICH were included in the study. The median age of patients on admission was 63.0 years, and 37.5% of them were women. Based on the baseline BUN/CR, 59,153 (70.4%) patients were classified into dehydration group. Patients with admission dehydration (BUN/CR ≥ 15) had 13% lower risks of in-hospital mortality than those without dehydration (BUN/CR < 15, adjusted OR = 0.87, 95%CI 0.78-0.96). In patients aged <65 years, admission dehydration was associated with 19% lower risks of in-hospital mortality (adjusted OR = 0.81, 95%CI 0.70-0.94. adjusted p = 0.0049) than non-dehydrated patients. Conclusion: Admission dehydration is associated with significantly lower in-hospital mortality after ICH, in particular, in patients <65 years old.

Keywords: blood urea nitrogen; creatinine; dehydration; intracranial hemorrhage; mortality.