Cohort profile: the Chinese Pregnant Women Cohort Study and Offspring Follow-up (CPWCSaOF)

Tianchen Lyu; Yunli Chen; Yongle Zhan; Yingjie Shi; Hexin Yue; Xuan Liu; Yaohan Meng; Ao Jing; Yimin Qu; Haihui Ma; Ping Huang; Dongmei Man; Xiaoxiu Li; Hongguo Wu; Jian Zhao; Guangliang Shan; Yu Jiang

doi:10.1136/bmjopen-2020-044933

Cohort profile: the Chinese Pregnant Women Cohort Study and Offspring Follow-up (CPWCSaOF)

BMJ Open. 2021 Mar 23;11(3):e044933. doi: 10.1136/bmjopen-2020-044933.

Authors

Tianchen Lyu^#¹, Yunli Chen^#¹, Yongle Zhan¹, Yingjie Shi¹, Hexin Yue¹, Xuan Liu¹, Yaohan Meng¹, Ao Jing¹, Yimin Qu¹, Haihui Ma², Ping Huang³, Dongmei Man⁴, Xiaoxiu Li⁵, Hongguo Wu⁶, Jian Zhao⁷, Guangliang Shan⁸, Yu Jiang⁹

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Obstetrics, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.
³ Department of Nutrition, First Affiliated Hospital of Nanchang University, Nanchang, China.
⁴ Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, China.
⁵ Department of Pediatric Gastroenterology, Dongguan Maternal and Child Health Care Hospital, Dongguan, China.
⁶ Department of Perinatal Health, Jiaxian Maternal and Child Health Care Hospital, Jiaxian, China.
⁷ Department of Nutrition and Food Safety, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁸ Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
⁹ Department of Epidemiology and Biostatistics, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China jiangyu@pumc.edu.cn.

^# Contributed equally.

Abstract

Purpose: A multicentre prospective cohort study, known as the Chinese Pregnant Women Cohort Study (CPWCS), was established in 2017 to collect exposure data during pregnancy (except environmental exposure) and analyse the relationship between lifestyle during pregnancy and obstetric outcomes. Data about mothers and their children's life and health as well as children's laboratory testing will be collected during the offspring follow-up of CPWCS, which will enable us to further investigate the longitudinal relationship between exposure in different periods (during pregnancy and childhood) and children's development.

Participants: 9193 pregnant women in 24 hospitals in China who were in their first trimester (5-13 weeks gestational age) from 25 July 2017 to 26 November 2018 were included in CPWCS by convenience sampling. Five hospitals in China which participated in CPWCS with good cooperation will be selected as the sample source for the Chinese Pregnant Women Cohort Study (Offspring Follow-up) (CPWCS-OF).

Findings to date: Some factors affecting pregnancy outcomes and health problems during pregnancy have been discovered through data analysis. The details are discussed in the 'Findings to date' section.

Future plans: Infants and children and their mothers who meet the criteria will be enrolled in the study and will be followed up every 2 years. The longitudinal relationship between exposure (questionnaire data, physical examination and biospecimens, medical records, and objective environmental data collected through geographical information system and remote sensing technology) in different periods (during pregnancy and childhood) and children's health (such as sleeping problem, oral health, bowel health and allergy-related health problems) will be analysed.

Trail registration number: CPWCS was registered with ClinicalTrials.gov on 18 January 2018: NCT03403543. CPWCS-OF was registered with ClinicalTrials.gov on 24 June 2020: NCT04444791.

Keywords: epidemiology; obstetrics; paediatrics; public health.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Child
China / epidemiology
Cohort Studies
Female
Follow-Up Studies
Humans
Infant
Pregnancy
Pregnant Women*
Prospective Studies

Associated data

ClinicalTrials.gov/NCT04444791
ClinicalTrials.gov/NCT03403543